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Substance is derived from the Latin substare, to stand beneath. It is the essential "something" that underlies everything we can sense, and enables us to "understand" its existence.
When we look up the definitions of words like matter, material, or substance in a dictionary, we encounter a confusion of circumlocutions and metaphors which might lead us to suppose that they all mean the same thing. To preserve the distinction between matter and substance, I shall take matter to mean that which seems to occupy space and to possess inertia, leaving substance to refer to whatever underlies the material appearance. This "restoration" of meaning seems necessary to take cognisance of the distinction between classical physics and quantum theory.
To create is to bring into existence. It does not mean the same as to construct, which is to put together or build something from matter which already exists. Blurring the important distinction between creation and construction impoverishes the language.
Science is the study of the physical world and the resulting body of scientific knowledge about physical things. Scientists are people who enhance and apply the methods of science in the quest for knowledge. They discover many wonderful things about the physical world, but to say that science creates, or even constructs, miracle substances is to confuse science and scientists, if not with the Creator, at least with technology and technologists.
Technology is the commercially motivated study, development and application of scientific knowledge to the synthesis of compound materials and to the construction, production and manufacture of goods and appliances which have potential for increasing the power, or enhancing the physical ease and comfort, of human beings.
Technologists are happy to be referred to as scientists because it confers upon them an aura of respectable moral authority and thus obscures their essentially commercial motivation. Academic "scientists" find it "comfortable" to put up with inherently contradictory dogmas because they need to obtain "funding" for their researches, and vested interests do not ordinarily invest in mavericks who are liable to upset their apple-carts. There are relatively few genuine scientists left in the world. Those who challenge "established" authority tend to be ostracised and find it almost impossible to hold academic posts or publicise their ideas in "learned" journals.
In particular, it contrives to blind us to the one and only miracle — the Creation, ab initio, of the Universe and all that it contains, including ourselves.
The inventor may conceive an idea, but its realisation in material form is, more often than not, only construction. It is only greed that makes a multinational corporation seek a restrictive patent on something that has been awaiting discovery from the foundation of the world. It is only ignorant arrogance for any of us to overlook the Creator Who stands under everything of which we can be conscious.